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Contributions to Science

Platelet transcriptome yields progressive markers in chronic myeloproliferative neoplasms and identified potential targets of therapy, 2021

Shen Z, Du W, Perkins C, Fechter L, Natu V, Maecker H, Rowley J, Gotlib J, Zehnder JL, Krishnan A

Predicting disease natural history remains a particularly challenging endeavor in cancer, thus limiting early detection, risk stratification, and preventive interventions. Here, profiling the spectrum of chronic myeloproliferative neoplasms (MPNs) as a model, we identify the blood platelet transcriptome as a generalizable strategy for highly sensitive progression biomarkers that also enable prediction via machine learning algorithms. Using RNA sequencing (RNA-seq), we derive disease-relevant gene expression and alternative splicing in purified platelets from 120 peripheral blood samples constituting two independently collected and mutually validating cohorts of the three MPN subtypes – essential thrombocythemia, ET (n=24), polycythemia vera, PV (n=33), and primary or post ET/PV myelofibrosis, MF (n=42), as well as healthy donors (n=21).

Platelet Heterogeneity in Myeloproliferative Neoplasms, 2021

Thomas S, Krishnan A


Platelet Transcriptomic Signatures in Myeloproliferative Neoplasms, 2017

Krishnan A, Zhang Y,  Perkins C, Gotlib J, Zehnder JL, Blood (2017), 130 (1) :5288

Select peer-reviewed publications (out of 17 total) prior to the 5-year research career gap:

The Effect of Surface Contact Activation and Temperature on Plasma Coagulation with an RNA Aptamer Directed Against Factor IXa

Krishnan A, Vogler EA, Sullenger BA, Becker RC, J Thromb. Thrombolysis 35: 48-56, 2013

Antithrombotic and Thrombolytic Therapy in Acute Ischemic Stroke: Guidelines Translated for the Clinician 

Krishnan A, Lopes RD, Alexander JH, Becker RC, Goldstein LB, J Thromb Thrombolysis, 29: 368-77; 2010

Interfacial energetics of Blood Plasma and Serum Adsorption to a Hydrophobic Self-assembled Monolayer Surface

Krishnan A, Liu YH, Cha P, Allara D, Vogler EA, Biomaterials, 27: 3187-3194, 2006

Mixology of Protein Solutions and the Vroman Effect

Krishnan A, Siedlecki CA, Vogler EA, Langmuir; 20: 5071-5078, 2004

See complete list of published work here